Relationship between morphometric parameters of epicardial adipose tissue and adipocytokine profile in patients with myocardial infarction

Abstract Aims To reveal the relationship between thickness of epicardial adipose tissue (EAT) and levels adiponectin, leptin, interleukins (IL) IL-6, IL-10, IL-12, IL-33 in blood serum patients with myocardial infarction. Materials methods A total 119 ST-segment elevation infarction (MI) who signed voluntary informed consent were examined. The left right ventricles (LV EAT RV EAT, respectively) was assessed using magnetic resonance imaging on an Exelart Atlas 1.5 MR tomograph (Toshiba, Japan). concentration studied parameters determined by ELISA method 1st 12th days hospitalization: adiponectin leptin (BioVendor, USA), (eBiosciens, USA). Statistical analysis performed Statistica 9.0. Results LV 6.3 (4.7; 9.5) mm, 6.8 (4.9; 0.6) mm. concentrations day 7.72 (6.5; 13.0) μg/ml, 7.48 (5.98; 12.5) ng/ml, IL-6 14.5 (11.6; 21.8) pg/ml, IL-10 1.9 (0.7; 2.5) IL-12 128.7 (66.4; 182.0) 5.6 (3.4; 7.2) ng/ml. On day, there increase level times, 2 a decrease 1.6 1.4 times 1.3 times. Correlation revealed following serum: (r=−0.29; p=0.01), 12st (r=0.36; p=0.03), (r=−0.64; p=0.046), (r=0.24; p=0.04). correlated (r=−0.59; p=0.01). Conclusions data obtained indicate presence morphometric characteristics adipocytokine profile MI. Based this, we can conclude about ability markers under study to reflect their potential use for development correcting pathological activation Funding Acknowledgement Type funding sources: None.